[Md Abdul Bari]

Biotechnology, particularly CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), has revolutionized disease resistance in poultry by enabling precise genetic modifications. Here’s how it influences disease resistance:

1. Enhanced Resistance to Viral Diseases

CRISPR can be used to edit specific genes that make poultry susceptible to viral infections like avian influenza, Marek’s disease, and Newcastle disease.

For example, researchers have successfully used CRISPR to modify genes in chickens to make them resistant to avian leukosis virus (ALV).

2. Improved Immune System Function

Scientists can edit genes that regulate the immune response, making poultry more efficient at fighting off infections.

For instance, modifying the TLR (Toll-like receptor) genes can enhance innate immunity.

3. Elimination of Disease-Carrying Genes

Some genetic traits make chickens more vulnerable to pathogens. CRISPR can disable or alter these genes, reducing disease susceptibility.

A good example is editing the ANP32A gene to make chickens resistant to avian influenza.

4. Development of Disease-Tolerant Breeds

Genetic engineering can be used to introduce disease-resistant traits into poultry breeds without affecting their growth rate, egg production, or meat quality.

This reduces the need for antibiotics and vaccines, lowering production costs and improving sustainability.

[Md.Rejuan Hossain]

CRISPR/cas9 can also be used to substitute the chANP32A gene with huANP32A that has enhanced avian polymerase activity in avian cells. This could impair the enhanced polymerase activity of the avian influenza virus in chicken cells, thereby providing resistance to poultry species against influenza.

[Md. Osman Sheikh]

Biotechnology, particularly CRISPR technology, can significantly enhance disease resistance in poultry by allowing scientists to precisely edit the poultry’s genome, introducing genetic modifications that disrupt the virus’s ability to infect the bird by altering key host proteins that the virus relies on for replication.

[Amir]

Biotechnology, particularly CRISPR technology, can significantly enhance disease resistance in poultry by allowing scientists to precisely edit the chicken genome, introducing genetic modifications that make the birds less susceptible to specific pathogens, often by targeting genes that viruses or bacteria use to infect the host cells, thereby improving their immune response and overall resilience to disease